Final Program
Wednesday, 01.03.2023
09:00 Registration / Coffee
10:20 Welcome (CIBSS Speakerteam)
10:30 Session 1: Signal integration at receptor complexes
Chair: Wolfgang Driever
10:30 – 10:55 Jiri Friml (ISTA, Klosterneuburg): Knowns and unknowns in auxin signalling
10:55 – 11:20 Claudine Kraft (University of Freiburg): Spatial confinement and avidity drive autophagosome formation
11:20 – 11:45 Nikolaus Pfanner (University of Freiburg): Mitochondrial machineries for import and assembly of proteins
11:45 – 12:10 Carola Hunte (University of Freiburg): Regulators of sodium/proton exchangers
12:10 – 12:25 Nadine Wössner (University of Freiburg): Novel approach to modulate T cell activation: from molecular mechanism to control of function
12:25 – 14:00 Lunch Break
14:00 Session 2: Integration of physical and chemical signals
Chair: Elke Barbez
14:00 – 14:25 Alba Diz-Munoz (EMBL Heidelberg): More than the sum: How does a composite interface govern function at the cell surface
14:25 – 14:50 Robert Grosse (University of Freiburg): Regulation, function and disease mechanism by nuclear actin assembly
14:50 – 15:15 GV Shivashankar (ETH Zürich): Nuclear mechanotransduction and cell-state transitions
15:15 – 15:30 Florencia Sanchez (University of Frankfurt): Ligand-free in situ confinement for GPCR activation and signal transduction
15:30 – 16:10 Coffee Break
16:10 Session 3: Signal integration by transcriptional and epigenetic complexes
Chair: Thomas Laux
16:10 – 16:35 Nelson Gekara (Institute of Medical Microbiology and Hygiene, University Medical Center Freiburg): Role of the DNA sensors in Innate Immunity and Genome Stability
16:35 – 17:00 Sebastian Arnold (University of Freiburg): Signalling to chromatin: The epigenetic logic of first lineage specification during pluripotency exit
17:00 – 17:15 Sukayna Guhathakurta (MPI-IE): MOF is an epimetabolic enzyme ensuring mitochondrial integrity via protein acetylation
17:15 10 Poster Flashtalks
17:45 Poster Session 1 and Get-Together with Fingerfood
Thursday, 02.03.2023
09:00 Session 4: Signal integration by signaling pathway components
Chair: Peter Walentek
09:00 – 09:25 Crina Nimigean (Weill Cornell Medical College, New York): Mechanism of lipid and voltage gating in cyclic nucleotide-modulated ion channels
09:25 – 09:50 David Mick (Saarland University, Homburg): Primary cilium proteome dynamics during active Hedgehog signaling revealed by APEX-based proximitylabeling
09:50 – 10:15 Sonja Albers (University of Freiburg): PP2A, a key signalling hub throughout evolution
10:15 – 10:40 Michael Rape (UC Berkeley): Ubiquitin-dependent stress signaling at the crossroads of development and disease
10:40 – 10:55 Svenja Wöhrle (University Medical Center Freiburg): NEK7 accelerates NLRP3 inflammasome activation
10:55 – 11:30 Coffee Break
11:30 Session 5: Integration of signals with metabolism
Chair: Anna Köttgen / Wolfgang Driever
11:30 – 11:55 Kathrin Kierdorf (University of Freiburg): Stress test for phagocytes: new insights on Drosophila macrophages and how they help to control systemic cytokine levels and energy mobilization during oxidative stress
11:55 – 12:20 Thomas Langer (MPI Köln): Programming cell fate by mitochondrial proteolysis
12:20 – 12:45 Nils Wiedemann (University of Freiburg): Mitochondrial biogenesis: Targeting signal-mediated protein translocation and membrane insertion
12:45 – 13:10 Nils Göran-Larsson (Karolinska Institut, Stockholm): Expression of mammalian mtDNA and organization of the respiratory chain
13:10 - 13:25 Sjon Hartman (University of Freiburg): Remember the Rain: Unravelling How Plants Encode Flooding Stress Memory
13:25 – 14:15 Lunch Break
14:15 – 14:45 Meet the Speakers
14:45 Session 6: Signalling integration across temporal and spatial scales
Chair: Björn Lillemeier
14:45 – 15:10 Thomas Ott (University of Freiburg): Engineering symbiont-induced organogenesis in non-host plants
15:10 – 15:35 Ertugrul Özbudak (Cincinnati Children's Hospital Medical Center): Reengineering somite segmentation without the vertebrate segmentation clock
15:35 – 16:00 Anne Classen (University of Freiburg): Spatio-temporal organization of tissue repair and regeneration
16:00 – 16:25 Guillermo Martinez-Ara (EMBL Barcelona): Optogenetic manipulation of shape in cerebral organoids
16:25 – 16:40 Christian Schröter (MPI Dortmund): Embryo-like stem cell aggregates reveal new signaling mechanisms for mammalian axis patterning
16:40 – 17:15 Coffee Break
17:15 10 Poster Flash Talks
17:45 Poster Session Nr. 2
19:30 Get together with drinks and music
Friday, 03.03.2023
09:00 Welcome (PRFI Rensing, University of Freiburg)
09:05 Session 7: Integration of intrinsic and extrinsic / environmental signals
Chair: Thomas Ott
09:05 – 09:30 Michael Holdsworth (University of Nottingham): Integration and adaptation to environmental signals through the plant N-degron pathways
09:30 – 09:55 Jürgen Kleine-Vehn (University of Freiburg): Growth integration in plants
09:55 – 10:20 Nina Cabezas-Wallscheid (MPI-IE): Regulation of hematopoietic stem cell dormancy
10:20 – 10:45 Mingjie Zhang (HK University of Science and Technology, Hongkong): Phase separation in synapse formation and function
10:45 – 11:10 Dolf Weijers (Wageningen University): Towards the evolutionary roots of auxin response
11:10 – 11:40 Coffee Break
11:40 Session 8: From Control of function to innovation
Chair: Henning Jessen
11:40 – 12:05 Wilfried Weber (University of Freiburg): Molecular Optogenetics - Programming Gene Expression with Light
12:05 – 12:30 Natalie Köhler (University Medical Center Freiburg): Defensins as treatment approach for acute graft-versus-host disease
12:30 – 12:55 Luc Brunsveld (University of Eindhoven): Alternative modes of regulation of Nuclear Receptor activity – from ligands to function
12:55 – 13:10 Anna Wolfers (University Medical Center Freiburg): A STAT1 variant beyond the gain- or loss-of function dichotomy offers opportunity for targeted intervention
13:10 – 13:25 Barbara Di Ventura (University of Freiburg): Requirements for mammalian promoters to decode transcription factor dynamics
13:25 Farewell remarks (CIBSS Speakerteam)
13:30 Lunch
END OF THE MEETING