March 1-3, 2023
Freiburg im Breisgau, Germany

International Symposium
Integration in Biological Signalling

Final Program

Download program as pdf

Wednesday, 01.03.2023

09:00   Registration / Coffee

10:20                                      Welcome (CIBSS Speakerteam)

10:30   Session 1:                 Signal integration at receptor complexes

                                               Chair: Wolfgang Driever

10:30 – 10:55   Jiri Friml (ISTA, Klosterneuburg): Knowns and unknowns in auxin signalling

10:55 – 11:20   Claudine Kraft (University of Freiburg): Spatial confinement and avidity drive autophagosome formation

11:20 – 11:45   Nikolaus Pfanner (University of Freiburg): Mitochondrial machineries for import and assembly of proteins

11:45 – 12:10  Carola Hunte (University of Freiburg): Regulators of sodium/proton exchangers    

12:10 – 12:25  Nadine Wössner (University of Freiburg): Novel approach to modulate T cell activation: from molecular mechanism to control of function


12:25 – 14:00                         Lunch Break


14:00   Session 2:                 Integration of physical and chemical signals

                                               Chair: Elke Barbez

14:00 – 14:25  Alba Diz-Munoz (EMBL Heidelberg): More than the sum: How does a composite interface govern function at the cell surface

14:25 – 14:50   Robert Grosse (University of Freiburg): Regulation, function and disease mechanism by nuclear actin assembly

14:50 – 15:15   GV Shivashankar (ETH Zürich): Nuclear mechanotransduction and cell-state transitions

15:15 – 15:30   Florencia Sanchez (University of Frankfurt): Ligand-free in situ confinement for GPCR activation and signal transduction


15:30 – 16:10                         Coffee Break


16:10   Session 3:     Signal integration by transcriptional and epigenetic complexes

                                  Chair: Thomas Laux

16:10 – 16:35  Nelson Gekara (Institute of Medical Microbiology and Hygiene, University Medical Center Freiburg): Role of the DNA sensors in Innate Immunity and Genome Stability          

16:35 – 17:00 Sebastian Arnold (University of Freiburg): Signalling to chromatin: The epigenetic logic of first lineage specification during pluripotency exit

17:00 – 17:15  Sukayna Guhathakurta (MPI-IE): MOF is an epimetabolic enzyme ensuring mitochondrial integrity via protein acetylation


17:15                         10 Poster Flashtalks  

17:45                          Poster Session 1 and Get-Together with Fingerfood


Thursday, 02.03.2023

09:00   Session 4:                 Signal integration by signaling pathway components

                                               Chair: Peter Walentek

09:00 – 09:25  Crina Nimigean (Weill Cornell Medical College, New York): Mechanism of lipid and voltage gating in cyclic nucleotide-modulated ion channels

09:25 – 09:50  David Mick (Saarland University, Homburg): Primary cilium proteome dynamics during active Hedgehog signaling revealed by APEX-based proximitylabeling

09:50 – 10:15 Sonja Albers (University of Freiburg): PP2A, a key signalling hub throughout evolution

10:15 – 10:40  Michael Rape (UC Berkeley): Ubiquitin-dependent stress signaling at the crossroads of development and disease

10:40 – 10:55 Svenja Wöhrle (University Medical Center Freiburg): NEK7 accelerates NLRP3 inflammasome activation


10:55 – 11:30                         Coffee Break


11:30   Session 5:                 Integration of signals with metabolism

                                               Chair: Anna Köttgen / Wolfgang Driever

11:30 – 11:55  Kathrin Kierdorf (University of Freiburg): Stress test for phagocytes: new insights on Drosophila macrophages and how they help to control systemic cytokine levels and energy mobilization during oxidative stress

11:55 – 12:20  Thomas Langer (MPI Köln): Programming cell fate by mitochondrial proteolysis

12:20 – 12:45  Nils Wiedemann (University of Freiburg): Mitochondrial biogenesis: Targeting signal-mediated protein translocation and membrane insertion

12:45 – 13:10  Nils Göran-Larsson (Karolinska Institut, Stockholm): Expression of mammalian mtDNA and organization of the respiratory chain  

13:10 - 13:25  Sjon Hartman (University of Freiburg): Remember the Rain: Unravelling How Plants Encode Flooding Stress Memory


13:25 – 14:15                          Lunch Break

14:15 – 14:45                         Meet the Speakers


14:45   Session 6:                 Signalling integration across temporal and spatial scales

                                               Chair: Björn Lillemeier

14:45 – 15:10  Thomas Ott (University of Freiburg): Engineering symbiont-induced organogenesis in non-host plants

15:10 – 15:35  Ertugrul Özbudak (Cincinnati Children's Hospital Medical Center): Reengineering somite segmentation without the vertebrate segmentation clock     

15:35 – 16:00  Anne Classen (University of Freiburg): Spatio-temporal organization of tissue repair and regeneration

16:00 – 16:25   Guillermo Martinez-Ara (EMBL Barcelona): Optogenetic manipulation of shape in cerebral organoids

16:25 – 16:40   Christian Schröter (MPI Dortmund): Embryo-like stem cell aggregates reveal new signaling mechanisms for mammalian axis patterning


16:40 – 17:15                        Coffee Break


17:15    10 Poster Flash Talks

17:45    Poster Session Nr. 2

19:30     Get together with drinks and music


Friday, 03.03.2023

09:00                                      Welcome (PRFI Rensing, University of Freiburg)

09:05  Session 7:                  Integration of intrinsic and extrinsic / environmental signals

                                               Chair: Thomas Ott

09:05 – 09:30  Michael Holdsworth (University of Nottingham): Integration and adaptation to environmental signals through the plant N-degron pathways

09:30 – 09:55  Jürgen Kleine-Vehn (University of Freiburg): Growth integration in plants

09:55 – 10:20  Nina Cabezas-Wallscheid (MPI-IE): Regulation of hematopoietic stem cell dormancy

10:20 – 10:45  Mingjie Zhang (HK University of Science and Technology, Hongkong): Phase separation in synapse formation and function

10:45 – 11:10 Dolf Weijers (Wageningen University): Towards the evolutionary roots of auxin response

11:10 – 11:40                         Coffee Break

11:40 Session 8:                   From Control of function to innovation

                                               Chair: Henning Jessen

11:40 – 12:05  Wilfried Weber (University of Freiburg): Molecular Optogenetics - Programming Gene Expression with Light

12:05 – 12:30  Natalie Köhler (University Medical Center Freiburg): Defensins as treatment approach for acute graft-versus-host disease

12:30 – 12:55 Luc Brunsveld (University of Eindhoven): Alternative modes of regulation of Nuclear Receptor activity – from ligands to function

12:55 – 13:10 Anna Wolfers (University Medical Center Freiburg): A STAT1 variant beyond the gain- or loss-of function dichotomy offers opportunity for targeted intervention

13:10 – 13:25 Barbara Di Ventura (University of Freiburg): Requirements for mammalian promoters to decode transcription factor dynamics       


13:25                                      Farewell remarks  (CIBSS Speakerteam)

13:30                                      Lunch




Download program as pdf